Recognition & Sources

Date of last review: August 1, 2020. A full review and update will be completed every 2 years with interim updates as new research becomes available.

The information in this decision aid was summarized from clinical practice guidelines, literature, and credible organizations. The development was guided by the International Patient Decision Aid Standards criteria.


Lee SJ, Schover LR, Partridge AH, et al. American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. J Clin Oncol. 2006;24(18):2917-2931.

Loren AW, Mangu PB, Beck LN, et al. Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update.J Clin Oncol. 2013;31(19):2500-2510.

Fertility Options

Wait and See

Expert Opinion and Speroff L, Fritz M. Clinical gynecologic endocrinology and infertility. 8th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; c2011. Chapter 27, Fertility and Aging; p. 1488.

Embryo Freezing and Egg Freezing

Expert Opinion and Canadian Assisted Reproductive Technologies Registry (CARTR) Plus. Final treatment cycle and pregnancy outcome data for 2014. Better Outcomes Registry & Network Ontario. Ottawa ON, September 2016.

Expert Opinion and American Society for Reproductive Medicine. Age and Fertility. Retrieved on October 31, 2016.

Cil AP, Bang H, Oktay K. Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis. Fertility and sterility. 2013;100(2):492-499. e493.

American Society of Reproductive Medicine. Risks of In Vitro Fertilization (IVF). Retrieved on October 31, 2016.

Corbett S, Shmorgun D, Claman P, et al. The prevention of ovarian hyperstimulation syndrome. Journal of Obstetrics and Gynaecology Canada. 2014;36(11):1024-1033

Ovarian Suppression

Lambertini M, Ceppi M, Poggio F, et al. Ovarian suppression using luteinizing hormone-releasing hormone agonists during chemotherapy to preserve ovarian function and fertility of breast cancer patients: a meta-analysis of randomized studies. Annals of Oncology. 2015.

In Vitro Maturation

McGill University Health Centre. In Vitro Maturation (IVM). Accessed August 30, 2016.

Human Fertilization & Embryo Authority. What is in vitro maturation (IVM) and how does it work? Accessed on August 31, 2016.

General References

Azim HA, Kroman N, Paesmans M, et al. Prognostic Impact of Pregnancy After Breast Cancer According to Estrogen Receptor Status: A Multicenter Retrospective Study. Journal of Clinical Oncology. 2012.

Azim HA, Jr., Santoro L, Pavlidis N, et al. Safety of pregnancy following breast cancer diagnosis: a meta-analysis of 14 studies. Eur J Cancer;47:74-83., 2016.

Canadian Cancer Society, 2016.

Cardonick EH. Overview of infertility and pregnancy outcome in cancer survivors. UptoDate. 2016.

Dalberg K, Eriksson J, Holmberg L. Birth outcome in women with previously treated breast cancer-a population-based cohort study from Sweden. PLoS Med. 2006;3(9):e336.

Duffy C, Allen S. Medical and Psychosocial Aspects of Fertility After Cancer. Cancer journal (Sudbury, Mass). 2009;15(1):27-33.

Fertile Future, 2016.

Lambertini M, Del Mastro L, Pescio MC, et al. Cancer and fertility preservation: international recommendations from an expert meeting. BMC Medicine. 2016;14(1):1-16.

Partridge AH, Ruddy KJ. Fertility and adjuvant treatment in young women with breast cancer. The Breast.2007;16:175-181.

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